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Biomaterials 258, 120278

doi: 10.1161/CIRCRESAHA.116.303587 258 ReyPLopez-RealASanchez-IglesiasSMuozASoto-OteroRLabandeira-GarciaJL

The administration of 300 mg/100 mg nirmatrelvir/ritonavir once on Day 1 followed by 150 mg/100 mg nirmatrelvir/ritonavir once daily on Days 2-5 in subjects with severe renal impairment, either requiring intermittent hemodialysis or not requiring hemodialysis resulted in comparable exposures on Day 1 and at steady-state (AUC0-24 and Cmax) compared to those observed in subjects with normal renal function receiving 300 mg/100 mg nirmatrelvir/ritonavir twice daily for 5 days

Chirieac LR, Swisher SG , Ajani JA, Komaki RR, Correa AM, Morris JS, Roth JA, Rashid A, Hamilton SR, Wu TT

This observation can also be extended to another cancer cell line (Fig